The setup of the game is simple, but don't let that deceive you: we open on a small boy mourning
over a grave, then a cut scene that tells us the grave belongs to his mother, who was lost at sea. He was there: he tried to help, but couldn't save her. The boy is interrupted by his older brother, who is with their father. The father has fallen ill, and now it's your first task to bring him home in a cart that requires the two brothers to work together to operate. This is where you're introduced to the game's core, innovative control scheme. The left side of the controller (that is, the left stick and left shoulder trigger button) control the older brother, and the right side of the controller belongs to the little brother. Your viewpoint is akin to a bird's eye view, but will zoom in and out as necessary and to always display the two brothers on screen at once.

I must say, I don't think I ever fully got used to the controls. There were many, many moments though when the control scheme synergized and felt incredibly natural and fluid, allowing me to solve puzzles and claim a sense of accomplishment. Other times, I was acutely aware that my brain wouldn't allow the little brother to run left unless he was behind the big brother - like the left stick had to be "first" on the screen. The opposite holds true: when moving the two brothers right, the little brother (the right control stick) had to be on the right of the screen. But you could move them completely independently, and often times I would. There are many moments - many puzzles - that has one of the brothers staying put while the other throws a switch. The puzzles get more complex, and involve timely use of the action triggers. Swinging the two from point to point in later levels required concentration and thought.
As a result, I became conscious of how careful I would become with various puzzles. This is in stark contrast to other games, where typically you're rewarded with going through things as quickly as possible, or you just feel the need to do so on your own anyway. Patience was abundant while playing this game. You're rewarded with beautiful vistas, incredible environments and wonderful small touches throughout. As the brothers begin their journey for medicine, you run through the town and can interact with people and things, including a small girl with a ball. You can throw the ball around, play "monkey in the middle" and even throw that ball down a well, if you're so inclined. There are benches all over the world, representing an opportunity to view the world you're about to enter, or give you a break from adventuring to appreciate the beauty of the landscape.
All the characters speak in gibberish, so it's up to you to identify the subtleties in their mannerisms and their interactions with the environment to progress. It's not a difficult game by any means: clocking in at around three hours, the game is more of an experience than anything else, one which I highly recommend. And from here, there will be spoilers. If you plan on playing, I recommend leaving the article now.